1966 Volume 32 Issue 4 Pages 128-146
An investigation was done on the familial aggregation of blood pressure levels and the incidence of cerebrovascular diseases in the families of 257 pupils of both sexes at a high school in an inland farm area of the northeast part of Japan. The examination consisted from the items of blood pressure measurement, cold pressor test, electrocardiography, ocular fundus examination, urinary tests and measurements of stature. These data were compared between family groups of hypertensives and normotensives. 1. Polygenic mechanism for blood pressure regulation was suggested by normal distribution of blood pressure levels of the pupils, sex and age adjusted scores and the logarithmic converted blood pressures of the families. 2. Incidence of hypertensive pupils was significantly higher from hypertensive parents than from normotensive ones. The same tendency was established for the morbidity of hypertensives for the parents that the higher the blood pressure levels of the grand-parents the larger the incidence for the parents of the pupils. 3. The blood pressure levels, incidences of myocardial injuries and of cerebrovascular diseases were significantly higher for the group of the grand-parents of the hypertensive parents. However, the tendency was not seen for the group of grandfathers if divided to male and female subgroups. 4. Parent-child relationship indicated by regression coefficient of the sex-age-adjusted systolic blood pressures was almost near 0.0 between the male pupils and their fathers, also between the fathers and the grandfathers. However, the coefficients were about 0.2 and significant between the sets of the daughters and the fathers, the daughters and the mothers, and the sons and the mothers. 5. These findings reveal that familial aggregation of the blood pressure levels is influenced by maternal effects. This might mean that the effects of social and economic conditions of the families are more consistent than the biological inheritance.