ゴマ油を利用してのインフルエンザアジュバントワクチンの野外実験成績

抄録

The influenza vaccine now used is of an aqueous type : it causes many side-effects mainly consisting of influenza-like symptoms on inoculation, and its immune value is kept merely for a short period of time : thus, there are some problems to use the said vaccine . While, the mineral-oil adjuvant vaccine which has been developed from the standpoint of the immune effect is excellent in its effectiveness, but it has also some problems on using practically, as it causes induration including the carcinogenes due to mineral oil. The author examined the results of a metabolizable adjuvant vaccine in a field experiment, as it can be developed according to the success of making sesame oil adjuvant . Treatment of the virus with ether, which is presumed to be developed in future, was also examined. The vaccines examined and compared were five ; that is, an aqueous vaccine (Plain-V), its ether-treated one (ET-Plain-V), two sesame oil vaccines (Meta-V, ET-Meta-V .), and a mineral-oil vaccine (Mine-V). 1. The influenza-like symptoms due to side-effects appeared less with Plain-V, ET-Plain-V and Mine-V. 2. Redness was seen similarly with the five vaccines, but induration was hardly observed with Plain-V, ET-Plain-V, Meta-V, and ET-Meta-V. 3. The HI value was observed : 3 months after inoculation, Meta-V and ET-Meta-V showed the antibody value the same to that of Plain-V one month after inoculation ; thus, the former two exhibited a prolonged effect, which was however inferior to that of Mine-V. 4. The ether-treated vaccine was not so effective as expected in this experiment . Judging from the above results, the sesame-oil adjuvant vaccine can be employed instead of the vaccine now used.