血中ChE活性値に及ぼす農薬散布の影響に関する研究

抄録

The present study was conducted for the purpose of investigating the influence of agricultural chemicals such as organic phosphoric compounds and carbamate derivatives on the blood cholinesterase levels of farmers working with the chemicals. The subjects of the investigation were 30 farmers (18 males and 12 females) who had worked with agricultural chemicals. Levels of cholinesterase (CHE) in their whole blood, plasma and hematocytes were measured for one year. The results were as follows: 1) Remarkable decreases in the CHE levels were observed in both males and females during the months when they worked with the agricultural chemicals. The females showed more remarkable decreases than the males. 2) Remarkable decreases in the ChE levels in Erythrocytes were observed in both males and females during the months when they worked with the agricultural chemicals. There was no difference in the decrease between the males and the females. 3) The ChE levels in plasma revealed such small decreases that the values were not suitable for utilization as indicators of the health condition of farmers exposed to agricultural chemicals. In consideration of these results, the CHE levels in whole blood and erythrocytes were regarded as suitable indicators of the influence of exposure to agricultural chemicals. As a relationship was observed between CHE levels and time of exposure to agricultural chemicals, it was concluded that the agricultural chemicals did influence the physical conditions of farmers exposed to them.