The features were studied concerning adult females under 49 years old living in Shiramine-village, Ishikawa Prefecture feeling coldness in some part of the body. The results obtained were as follows. 1. Frequency of females feeling coldness in some part of the body increased with age. 2. The part of the body in which the subjects felt coldness most frequently were the lower limbs. 3. In the thirties, frequency of smoking in females feeling coldness in some part of the body was higher than that in females not feeling coldness. in the fourties, serum HDL cholesterol in females feeling coldness in some part of the body was significantly lower than that in females not feeling coldness. In addition, atherogenic index (AI) in females feeling coldness was significantly higher than that in females not feeling coldness. These results suggest that in females there might be some relationship between feeling of coldness in the body and smoking, and/or feeling of coldness in the body and atherosclerosis.