1993 Volume 59 Issue 5 Pages 241-247
We conducted an epidemiological study on liver cancer in the former coalmining area of Chikuho where mortality from liver cancer was high, using the data on liver cancer mortality in lizuka Health Center in Fukuoka Prefecture. Using the Japanese mortality from liver cancer as standard, we found that the ratios of observed to expected deaths from liver cancer in the Iizuka Health Center District between 1986 and 1988 were 213 for males and 198 for females. Of those deceased from liver cancer, 17.4% were HBs antigen positive. A high positive rate of HBs antigen was particularly observed in the 30-39 age group (positive rate=100%) and the 40-49 age group (positive rate=42.9%) among the younger age groups. To clarify the relationship of liver cancer to HBs antigen, blood transfusion, drinking habits and smoking habits, we also conducted a case-control study. We analyzed 133 cases who had died of liver cancer and 132 controls who were randomly selected from inpatients in the three large hospitals in the Iizuka Health Center District. The relative risks were 10.23 for HBs antigen positive (p<0.001) and 2.33 for blood transfusion (p<0.01), which were statistically significant, but 1.20 for drinking and 1.59 for smoking, which were not statistically significant. HBs antigen positive and blood transfusion were significantly associated with liver cancer.