2002 年 68 巻 1 号 p. 19-24
The association of the angiotensin I converting enzyme gene (ACE) insertion-deletion (IID) polymorphism with hypertension and coronary heart disease has been reported. Moreover, the racial difference in genotypic and allelic frequencies of ACE was found. Comparing our data with the results of other references, we investigated the geographic differences in genotypic and al lelic frequencies of ACE I/D polymorphism in Japan. The geographic difference in genotypic and allelic frequencies of ACE was found. This difference among Japanese is interesting from an epidemiological point of view.