多重リスクファクター症候群に関与する遺伝要因・環境要因の統計遺伝学的解析

抄録

A statistical genetic analysis was conducted in order to evaluate to what extent the clustering of hypertension, hyperlipidemia, diabetes, and obesity are influenced by genetic or environmental factors. The subjects were adult 117 monozygotic (MZ) and 20 dizygotic (DZ) twin pairs of the graduates of attached senior high school to the Tokyo university, who answered a mailed questionnaire that covered cardiovascular risk factors and health behaviors. The frequencies of hypertension, hyperlipidemia, and diabetes in this study was ascertained from subjects' self-report of a physician diagnosis and/or the use of medications. The body mass index calculated from self-reports of height and maximum weight was used as a measure of obesity. Covariance structure analysis was performed using program packages PRELIS2 and LISREL8. The results demonstrated that (1) Probandwise concordance rates in MZ are higher than those of DZ, especially when the risk factors increase. (2) Univariate genetic analysis showed that the clustering of risk factors are influenced by the age of subjects (22%), additive genetic factors (46%), and specific environmental factors (32%). It is concluded that not only environmental factors, but genetic factors should be considered in the proper management of the clustering of the cardiovascular risk factors. Much attention should be paid to the family history of risk clustering.