微生物の圧力ストレス応答とトレハロースの役割

抄録

Trehalose (α-D-Glucopyranosyl α-D-glucopyranoside) is one of the disaccharides and exists widely in animals, plants and bacteria. In this article, the role of trehalose in microbial cells was discussed from the point of view of their stress response: synthesis of heat shock proteins and trehalose, and the induction of stress tolerance. Further-more, an outline of the behavior of microbes under high pressure was also given. The concrete contents of the article are (1) effects of trehalose on thermotolerance of pressure-shocked yeast, (2) effects of temperature and pressure on the death rate of Lactobacillus casei and Escherichia coil, (3) properties and functions of trehalose, (4) extreme barotolerance of tardigrade, and (5) correlation of thermotolerance and barotolerance of yeast and the mean number of equatorial OH groups in sugar molecules.