ラットα₂-acute phase protein (α₂-AP) のアジュバント関節炎抑制作用

抄録

Rat α₂-AP was isolated from the sera of turpentine induced inflammatory rats by an immunoaffinity chromatography and the inhibitory activity of α₂-AP on rat adjuvant arthritis was investigated.
Rat α₂-AP administration inhibited both the primary inflammation and the secondary inflammation (adjuvant arthritis) induced by Freund's complete adjuvant. The inhibitory effects of α₂-AP on adjuvant arthritis were found to be enhanced by inhibiting the primary inflammatory processes.