RA患者リンパ球上清による好中球の滑膜細胞傷害性の増強作用

抄録

PMN obtained from synovial fluids of patients with RA was cytotoxic on synovial cultured cells.
Supernatants of synovial lymphocytes of RA patients enhanced the cytotoxic activity of both synovial PMN of RA patients and peripheral PMN of normal subjects on synovial cultured cells.
Supernatants of synovial lymphocytes of RA patients treated with anti IFN-γ antibody did not enhanced the cytotoxic activity of the PMN on synovial cultured cells.
Recombinant IFN-γ enhanced the cytotoxic activity of peripheral PMN of normal subject.