Journal of Clinical and Experimental Hematopathology
Online ISSN : 1880-9952
Print ISSN : 1346-4280
Short Communication
Secondary Sea-blue Histiocytosis Derived from Niemann-Pick Disease
Osamu SuzukiMasafumi Abe
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2007 Volume 47 Issue 1 Pages 19-21


Sea-blue histiocytosis is a rare disorder seen in patients with lipid metabolic or ceroid storage diseases. Sea-blue histiocytes are ceroid-laden macrophages detectable by May-Giemsa staining. We report a case of a 28-year-old woman diagnosed with Niemann-Pick disease at 2 or 3 years of age. To confirm this diagnosis, we examined her bone marrow, which revealed scattered foci containing aggregates of foamy macrophages. May-Giemsa staining identified blue-staining foamy macrophages, referred to as sea-blue histiocytes. In summary, we report the detection of sea-blue histiocytosis in an adult with Niemann-Pick disease. [J Clin Exp Hematopathol 47(1) : 19-21, 2007]

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© 2007 by The Japanese Society for Lymphoreticular Tissue Research
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