Journal of Clinical and Experimental Hematopathology
Online ISSN : 1880-9952
Print ISSN : 1346-4280
Case Study
Spontaneous Regression of Diffuse Large B-Cell Lymphoma Harbouring Epstein-Barr Virus : A Case Report and eview of the Literature
Rokuo AbeKazuei OgawaYukio MaruyamaNaoya NakamuraMasafumi Abe
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2007 Volume 47 Issue 1 Pages 23-26


We report an elderly patient with diffuse large B cell lymphoma harbouring Epstein-Barr virus that showed spontaneous regressions with subsequent relapses three times. The patient died of aspiration pneumonia without any anti-neoplastic treatment 5 years 10 months after the initial onset of lymph node swelling. In the literature, there are several reports of aggressive non-Hodgkin's lymphoma cases that showed spontaneous regressions without relapse till the last observation. Over half of the cases were the extra-nodal type. The tendency toward regression of swollen lymph nodes detected by clinicians occurs within 2 weeks after biopsy. If the remaining lymph nodes show a tendency to decrease in size after biopsy without any anti-tumor therapies, the patient may develop spontaneous regression. [J Clin Exp Hematopathol 47(1) : 23-26, 2007]

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© 2007 by The Japanese Society for Lymphoreticular Tissue Research
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