Journal of Clinical and Experimental Hematopathology
Online ISSN : 1880-9952
Print ISSN : 1346-4280
ISSN-L : 1346-4280
Case Study
Fatal Visceral Varicella-Zoster Developing Early after Autologous Hematopoietic Stem Cell Transplantation for Refractory Diffuse Large B-Cell Lymphoma
Satoshi IchikawaMihyun KimShin HasegawaKeiichi OhashiAiko KondoHiroki KatoMayumi KamataYoko OkitsuNoriko FukuharaYasushi OnishiKenichi IshizawaHideo Harigae
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2014 Volume 54 Issue 3 Pages 237-241


A middle-aged woman who had undergone autologous hematopoietic stem cell transplantation (HSCT) 1 month previously suffered severe epigastralgia and relapse of lymphoma. The epigastralgia was not relieved by chemotherapy. Thereafter, her pancreatic and hepatic enzyme levels were markedly elevated and disseminated varicella emerged. Despite acyclovir administration, her general condition deteriorated rapidly and she died. Serum varicella zoster virus (VZV) DNA level was shown to be elevated and a diagnosis of disseminated VZV infection was established postmortem. In patients with severe abdominal pain following HSCT, early suspicion and therapeutic intervention for VZV are important, even in the absence of skin lesions.

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© 2014 by The Japanese Society for Lymphoreticular Tissue Research
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