Journal of Clinical and Experimental Hematopathology
Online ISSN : 1880-9952
Print ISSN : 1346-4280
Case Study
Spontaneous Regression of Intravascular Large B-Cell Lymphoma and Apoptosis of Lymphoma Cells: A Case Report
Tsutomu TakahashiFumiyoshi IkejiriSaki TakamiTakahiro OkadaSatoshi KumanomidouKoji AdachiJo YumiChie OnishiKoshi KawakamiIchiro MoriyamaMasaya InoueTakaaki MiyakeJunko TanakaRiruke MaruyamaJunji Suzumiya
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2015 Volume 55 Issue 3 Pages 151-156


  A 61-year-old Japanese woman presented with hemophagocytic syndrome (HPS) and suffered from intravascular large B-cell lymphoma (IVLBCL). After a few days of supportive care, her condition improved without any anti-cancer drugs or steroids. She experienced recurrences of HPS at 15 mon and 21 mon after first presentation, but lymphoma cells were not observed. Relapse of IVLBCL with pulmonary involvement occurred 27 mon after first presentation. She underwent R-CHOP therapy followed by autologous stem cell transplantation. She is currently alive and without lymphoma. Immunostaining by anti-ssDNA suggested that spontaneous regression may have been due to apoptosis of the lymphoma cells. [J Clin Exp Hematop 55(3) : 151-156, 2015]

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© 2015 by The Japanese Society for Lymphoreticular Tissue Research
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