Journal of Clinical and Experimental Hematopathology
Online ISSN : 1880-9952
Print ISSN : 1346-4280
ISSN-L : 1346-4280
Original Article
Potential anti-lymphoma effect of M-CSFR inhibitor in adult T-cell leukemia/lymphoma
Yoshihiro KomoharaOsamu NoyoriYoichi SaitoHiroto TakeyaMuhammad BaghdadiFumihito KitagawaNaoki HamaKozo IshikawaYutaka OkunoKisato NosakaKen-ichiro SeinoMasao MatsuokaShinya Suzu
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2018 Volume 58 Issue 4 Pages 152-160


The c-fms proto-oncogene is also known as macrophage colony stimulating factor receptor (M-CSFR) or colony-stimulating factor-1 receptor (CSF-1R), and is expressed on several types of malignant tumor cells and myeloid cells. In the present study, we found that overexpression of M-CSFR was present in adult T-cell leukemia/lymphoma (ATLL) cases. M-CSFR signaling was associated with lymphoma cell proliferation, and M-CSFR inhibition induced apoptosis in lymphoma cells. The ATLL cell line ATL-T expressed M-CSF/CSF-1 and interleukin (IL)-34, which are both M-CSFR ligands. M-CSF and IL-34 expression was seen in ATLL cases, and co-expression of these ligands was detected in 11 of 13 ATLL cases. M-CSFR inhibition suppressed programmed death-1 and -2 ligand in ATL-T cells and macrophages stimulated with conditioned medium from ATL-T cells. Thus, an M-CSFR inhibitor may be useful as additional therapy against ATLL due to direct and indirect mechanisms.

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© 2018 by The Japanese Society for Lymphoreticular Tissue Research
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