DA-EPOCH-R therapy for high-grade B-cell lymphoma with                        MYC and BCL2 and/or BCL6                    rearrangements in a patient with renal dysfunction

Masaki Mitobe; Keisuke Kawamoto; Takaharu Suzuki; Tatsuya Suwabe; Yasuhiko Shibasaki; Masayoshi Masuko; Kanako Inoue; Hiroaki Miyoshi; Koichi Ohshima; Hirohito Sone; Jun Takizawa

doi:10.3960/jslrt.20043

Case reports

DA-EPOCH-R therapy for high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements in a patient with renal dysfunction

Masaki Mitobe, Keisuke Kawamoto , Takaharu Suzuki, Tatsuya Suwabe, Yasuhiko Shibasaki, Masayoshi Masuko, Kanako Inoue, Hiroaki Miyoshi, Koichi Ohshima, Hirohito Sone, Jun Takizawa

著者情報

Masaki Mitobe
Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, Niigata University, Niigata, Japan,
Keisuke Kawamoto 責任著者
Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, Niigata University, Niigata, Japan,
Takaharu Suzuki
Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, Niigata University, Niigata, Japan,
Tatsuya Suwabe
Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, Niigata University, Niigata, Japan,
Yasuhiko Shibasaki
Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, Niigata University, Niigata, Japan,
Masayoshi Masuko
Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, Niigata University, Niigata, Japan,
Kanako Inoue
Department of Pathology, School of Medicine, Kurume University, Kurume, Japan
Hiroaki Miyoshi
Department of Pathology, School of Medicine, Kurume University, Kurume, Japan
Koichi Ohshima
Department of Pathology, School of Medicine, Kurume University, Kurume, Japan
Hirohito Sone
Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, Niigata University, Niigata, Japan,
Jun Takizawa
Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, Niigata University, Niigata, Japan,

キーワード: DA-EPOCH-R therapy, high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements, double-hit lymphoma, renal dysfunction, renal impairment

ジャーナルオープンアクセス

2021 年 61 巻 1 号 p. 42-47

DOI https://doi.org/10.3960/jslrt.20043

Browse “Advance online publication” version

詳細

抄録

High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements, also known as double-hit lymphoma, has been reported as refractory to R-CHOP therapy and requires more intensive regimens. However, intensive and safe regimens for patients with renal dysfunction are unknown. Herein, we report the successful use of DA-EPOCH-R therapy for double-hit lymphoma in a 64-year-old man with renal dysfunction. The patient had lymphoma-induced bilateral ureteral obstruction. Although renal dysfunction remained after removing the obstruction using R-CHOP therapy, we completed six cycles of DA-EPOCH-R therapy without any major adverse events. DA-EPOCH-R therapy may be a safe regimen for renal dysfunction patients.

責任著者(Corresponding author)

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