抄録
Five T cell lymphoma cases, which changed histological pictures between successive biopsies, were studied by Southern blot method with TCR β gene probe. Three cases showed disease progression from low grade to high grade peripheral T cell lymphoma. Two cases showed the histological changes between low grade lesions. Four of 5 cases showed clonal rearrangements of TCR β genes and both successive biopsied samples of each case showed the rearrangement bands of the same size. These results suggested that a single clone could make different histological pictures, which might be attributed to the change of lymphokine synthesis and secretion.
