Journal of the Japan Society of the Reticuloendothelial System
Online ISSN : 1883-6801
Print ISSN : 0386-9725
ISSN-L : 0386-9725
Apoptosis of T cells in multicentric Castleman's disease
Taijiro Ishiyama
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1995 Volume 35 Issue 5 Pages 247-255


Profound immunodeficiency in multicentric Castleman's disease (MCD) has already been indicated.
We evaluated immune function in four MCD patients. These results show: (1) polyclonal B cell activation in 4/4 patients, (2) decreased T cell colony formation in 3/4 patients, (3) decreased NK activity and NK cell number in 2/4 patients, (4) spontaneous IL-6 production in peripheral blood monocyte. These results showed that MCD resemble acquired immunodeficiency syndrome (AIDS).
Moreover, we indicated increased T cell activation in MCD, with this activation probably resulting in apoptosis. T cell apoptosis may be related to the pathogenesis of MCD.

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© by The Japanese Society for Lymphoreticular Tissue Research
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