2018 Volume 39 Issue 1 Pages 1-10
The present investigation was carried out to determine the levels of blood serum components and inflammatory cytokines in diabetic rat model [Goto-Kakizaki (GK), Zucker, and streptozotocin (STZ)-induced Sprague Dawley (SD) rats] underwent abdominal Light-Emitting Diode (LED) irradiation. The animals were subdivided into the following groups: diabetic control rats (GK, Zucker, STZ) and diabetic rats treated with LED (GK + LED, Zucker + LED, and STZ + LED) (n = 7). The animals were irradiated three times weekly for 12 weeks in LED (850 nm) at a dose of 10 J/cm2 for 500 s. Body weight was significantly lower in the Zucker-LED group compared to control at 10 weeks and this pattern was maintained until 12 weeks of age. TNF-α, IL-1β and IL-6 levels were significantly decreased (5.1 ± 1.1 vs. 3.8 ± 0.6, P < 0.05; 43.6 ± 8.8 vs. 29.8 ± 5.4, P < 0.05; 98.3 ± 15.8 vs. 68.1 ± 13.7, P < 0.01) in the Zucker-LED group compared with the control rats. Similarly, the serum levels of glucose, cholesterol and triglycerides of LED groups were decreased in comparison with that of diabetic control rats. In conclusion, we suggest that abdominal LED irradiation can reduce body weight and LED irradiation could be applicable for use against diabetic-induced inflammatory factors.
