Photodynamic Technology for Prostate Cancer

Abstract

In this review, photodynamic technology for managing prostate cancer is discussed. This treatment approach is divided into diagnostic and therapeutic uses. In cellular-targeted photochemotherapy, antitumor effects are conferred by irradiating cancer cells with photosensitizing substances, while in vascular-targeted photochemotherapy (VTP), these effects are conferred by irradiating vessels and their occlusions with photosensitizing substances. A phase III trial of VTP using WST11 as a focal therapy for prostate cancer has shown significant outcomes, and its clinical application has been anticipated. Regarding photodynamic diagnostics, the use of 5-aminolevulinic acid has been evaluated. However, further investigations are warranted to determine its efficacy in the clinical setting.