Design of Polymer-Based Drug Delivery Systems Targeting LAT1 and Their Application in Photodynamic Therapy

Abstract

In recent research for cancer therapy, L-type amino acid transporter 1 (LAT1), which is highly expressed on many cancer cells, has been recognized as a promising target molecule. Indeed, the utility of targeting LAT1 has already been demonstrated in clinical studies of boron neutron capture therapy (BNCT). We utilized the knowledge gained from BNCT research, developed drug delivery systems (DDSs) that target LAT1, and extended its application to photosensitizer delivery. This article introduces our recent research for LAT1-targeted photodynamic therapy (PDT).