Abstract
We made a basic study on the usefulness of photodynamic therapy of hepatoma with PH-1126 (Hamari chemicalas, Osaka, Japan) which is a new photosensitizer excreted in normal liver tissue in an early stage but localizing in tumor and report the result.
The examination to see the localization of PH-1126 in the course of time in the tumor area and normal liver tissue in the VX2 hepatoma model in rabbits disclosed that it was highly localized in the tumor area in the quantity about 60 times that in normal liver tissue 48 hours after administration. Laser irradiation (50mw, 80J/cm2) 48 hours after PH-1126 administration caused wedgeshaped tumor degeneration and necrosis but failed to exert sufficient effect onto deep tumor.
Accordingly, we had developed a new fiber tip (Moritex Ltd., Tokyo, Japan) suitable for intratumor puncture as a device for laser irradiation for deep-seated tumor like hepatoma and performed the study of its therapeutic effect.
We expect that in the future photodynamic therapy would be available in series of intensive therapeutic approaches to hepatoma
