抄録
Photodynamic effects of hematoporphyrin derivative(HpD), hematoporphyrin(Hp) and protoporphyrin (Pp) on cultured rat hepatocellular carcinoma cells (JTC-16), human hepatocellular carcinoma (HCC-1) and gastric cancer (GCA-1) serially transplanted in nude mice were studied, under the influence of a dye laser irradiation.
The cell degeneration was observed most strongly in Pp, HpD and then Hp in order. The tumor degeneration of HCC-1 was observed most strongly in Hp and then HpD in order. On the other hand, the tumor degeneration of GCA-1 was observed most strongly in HpD and then Hp in order. Photodynamic effect of Pp was not observed in both GCA-1 and HCC-1.
Therefore, it is suggested that Pp had the most powerful photodynamic effect on the cultured cells, but not on human cancer. This phenomenon would indicate that Pp has no affinity with the cancer tissue.
