Abstract
Increased power densities of delivered light can produce elevation in tissue temperature during photodynamic therapy.
We have performed a study to measure the temperature of I. Argon dye laser, (630nm. 200mw). IIGold vapor laser (628nm. 1712Hz. 3.5W) and IIIExcimer dye laser (0.3mJ and 3mJ/puls 1~60Hz). Experiments were performed using FM mouse mammary tumor in mice In-vivo temperature measurements were obtained on anesthetized animals using digital multiple meter (Takeda Riken Co., Ltd).
The temperature of laser beam shows 57°C in Argon dye laser, more than 65°C in Gold vapor laser, rise 10°C in excimer dye laser (60Hz). The temperature of tumor shows 32°C in Argon dye laser, more than 55°C in Gold vapor laser, but no change can be seen in excimer dye laser. There are no difference between HpD injected mouse tumor to control tumor on temperature.
Histological change can be seen on the HpD injected mouse tumor irradiated by excimer dye laser. This shows photodynamic effectiveness without high temperature effect.
