Abstract
For studying the effect of irradiation with pulsed GaAlAs laser diode on wound healing especially granulation tissue formation, fullthickness skin defects surrounded by resinous rings were made on the back of rats and were irradiated with the laser every day Dry weight and collagen production of granulation tissue on 14 p. o. d. were more increased than controls by the irradiation at an energy density of 0.6J/cm2. Pathological changes of the granulation tissue were described. Irradiation of pulsed GaAlAs laser diode may promote wound healing with a small energy.