胎盤から抽出した水溶性物質の鶏胎仔に及ぼす影響に就て

抄録

The author extracted water soluble substances from 10 months placenta, 3 months chorionic villi and from vesicular mole by Matsubara's method, and confirmed the presence of their active component by means of qualitative reactions and intracutaneous reactions. Upon the above confirmations, these substances were injected into developing hen's eggs in order to investigate their influence on the growth and the liver of the developing chick embryos. The following results were thus obtained.
1. The injection of fraction P.X extracted from 10 months placenta acted on the growth of chick embryo neither promotingly nor inhibitorily. Further, no histological findings in the liver suggesting any toxic changes were noted.
2. The injection of fraction P.X extracted from 3 months chorionic villi acted on the growth of the chick embryo promotingly at the concentration of 5 mg, but acted inhibitorily at the concentrations of more than 5 mg. However, no influence was recorded at the concentrations less than 5 mg. In this case, pathological changes were recognized in the liver at a high concentration (10mg), which were considered primarily to be venous circulatory impediment due to direct absorption of fraction P.X.
3. The injection of fraction P.X extracted from vesicular mole acted on the growth of chick embryo promotingly at a relatively low concentration (0.625mg), but inhibitorily at higher concentrations. However, it did not cause any pathological changes in the liver.