胎生期の薬理学的研究

覚醒アミン (Philopon) の鶏胎仔心臟及び腎臟に及ぼす影響に就て

抄録

Following their previous report, the authors investigated histologically the influences of the administration of Philopon exercised on the heart and kidney of the chick embryo. The results thus obtained were compared with those in the past and came to the following conclusions
1) As the findings in the heart, cellular infiltration and congested blood vessels in the pericardium and the enlargement and proliferation of the endothelial cells of the endocardium were recognized since the initial stage of the incubation. Generally, no particular findings were noted in the myocardium, but a mild regressive degeneration in the myocardium was observed in the cases where injections were given at a certain concentrations.
2) As the findings in the kidney in the initial stage of the incubation, the hyperemia and cellular infiltration were recognized. By the increase in the concentration, regressive degenerations such as granular degeneration, disappearance of nuclei and necrobiosis or necrosis were recognized in the urinary tubli since the initial stage of the incubation.