1958 年 18 巻 5 号 p. 388-395
The excitatory process of single nerve fiber of frog caused by electric stimulation have been studied.
Hashida have been already mentioned that there were two stages in the process of nervous reaction following electric stimulation. The first stage was the passive process, namely stimulatory process, and the second was that of the active one, namely excitatory process. The stimulatory process advanced during “Nutz Zeit” and the excitatory process advanced and finished during the latent period of the action potential following “Nutz Zeit”.
The latent period shortened increasingly by continuous electric stimulation of the same strength following “Nutz Zeit”. The minimum of the shortened period was 0.05-0.1 cosec.
On the contrary after the “Nutz Zeit” when electric current applied on the opposite direction, the prohibiting action was observed and the excitatory process was inhibited or even stopped. But when the stimulation applied after a certain period, no matter how strong the stimulation was, the prohibiting action did not occur.
From these observation we found that there were two stages in the excitatory process which made progress from the end of the “Nutz Zeit” to appearance of action potential. We pressume that the electrical mechanism acted in the first stage and the chemical process did in the second stage.