産婦人科領域に於けるCandidaに関する臨床的研究

抄録

1. Out of the total 426 patients examind, 92 cases (21.59%) were found to be positive of candida in their vagina.
2. The positive rate of pregnant women was 29.05% and non pregnant 17.62%.
3. The positive rate was high among the women of sexual maturity.
4. There was no seasonal variation in the rate of candida detection.
5. Out of the 65 candida strains isolated, C. albicans occupied 63.07% and its rate of detection among the patients with symptoms of candiasis was over 80%.
6. The rate of detection was higher on the vagina of higher cleanliness.
7. Candida negative cases became candida positive and developed its infection after the treatment with antibiotics. When antibiotics were used on candida positive cases, the number of onset cases increased. Thus, it was clarified that candida appeared as an alternative microorganisms as the rsult of antibiotic traatment.
8. Out of the 92 cases, those who developed candidiasis were 19 (20.6%) with the main complaint of pruritus vulvae (93.3%) .
9. Out of the 10 cases of new-borns examined, candida was positive in 1 case. It showed no symptoms of candidiasis and the source of infection was unknown.
10. On mice experimentally infected with candida by oral and intravenous inoculation, chlortetracycline was found to enhance its proliferation while Trichomycin inhibit.
11. Tests made on the 50 strains of candida isolated showed that Trichomycin inhibits their growth at a concetration 1.0-0.1 u/ml.
12. Both Trichomycin and Trichomycin-Penicillin (suppository) applied on 50 patients showed excellent clinical effects.