昭和医学会雑誌
Online ISSN : 2185-0976
Print ISSN : 0037-4342
ISSN-L : 0037-4342
病的筋の実験生化学的研究 (二, 三の孝素を中心として)
川上 勝久
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ジャーナル フリー

1968 年 28 巻 3 号 p. 162-171

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It was not until the last decade that the biochemical composition of muscles has been actively investigated. In order to know a morbid state of muscles more thoroughly, the authers carried out an animal experiment, in which the level of Na, K, mucoprotein, alkaline and acid phosphatase in the serum as well as the water content and enzymatic activities (alkaline and acid phosphatase, creatinekinase and succinic dehydrogenase) of the gastrocnemius were serially determined in animals who were preliminarily subjected to ischiatic neurotomy, fixation with Plaster cast or ligation of both the femoral vein and lymphatic vessels unilaterally to prepare morbid muscle preparations in situ.
The folloving results were obtained :
Ischiatic neurotomy was followed by a slight increase in Na, slight decrease in K, increase in the serum mucoprotein and acid phosphatase, marked increase in the muscle acid phosphatase as well as marked decrease in creatinekinase and succinic dehydrogenase activities.
After the fixation with Plaster cast there were slightly elevated Na, slightly lowered K, increased mucoprotein, and reduced creatinekinase and succinic dehydrogenase activities were noted.
With the ligation of the femoral vein and lymphatic vessels all these biological values, after the initial alteration, returned to normal range by the 2nd to 3rd week.
Thus, there was a difference in response to these procedures noted between mucoprotein, acid phosphatase, creatinekinase and succinic dehydrogenase.

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