A new plasma expander, hydroxyethyl starch solution (HES) was used clinically. The solution 500 ml was administrated in 15 minutes on 31 cases (male 15 cases, female 16 cases), having no concern with body weight, age and sex.
Cases were divided into two main groups, a group of only general anesthesia without operation (Anesthesia group) aan a group of receiving operation during general anesthesia (Surgery group) .
The results were follows:
1. Circulatory blood volume and plasma volume increased immediately after rapid infusion of HES and maintained up to 60-120 minutes.
2. 20-30% of HES was excreted in urine during 120 minutes.
3. Administration of HES has not effected upon acid-base balance and serum electrolytes.
4. Osmotic diuresis was observed, followed by increased urinary volume and decreased urinary osmolarity, in anesthesia group. Renal function seems not be affected by HES.
