血液疾患におけるCeruloplasminの臨床的検討
1973 年 33 巻 6 号 p. 753-768
詳細
1973 年 33 巻 6 号 p. 753-768
Serum ceruloplasmin values were determined by the revised method of Ravin in cases of hypoplastic anemia, iron deficiency anemia and leukemia, and clinical significance was investigated from serum ceruloplasmin level.
Results obtained were as follows.
1) Clinical improvement in hypoplastic anemia was seen in patients who had high serum ceruloplasmin value, but not in patients who had low ceruloplasmin value. Acute form which showed severe clinical symptomes such as bleeding and high fever was not improved in spite of having high serum ceruloplasmin value. There was negative correlation between serum ceruloplasmin value at the time of initial examination and hemoglobin value.
2) The frequency of iron deficiency anemia from serum ceruloplasmin level was 24% in low group ; 64 in normal (normal range : 20-30 mg/dl) ; 12 in high group.
3) The frequency of acute leukemia from serum ceruloplasmin level was 18% in low group ; 22 in normal group ; 60 in high group, and the frequency of chronic leukemia was 75% in low group and 25% in normal group. Serum ceruloplasmin value in the patients of acute leukemia tended to decrease towards end-stadium.
4) The combined use of human ceruloplasmin and folic acid was effective in 10 of 17 cases of hypoplastic anemia, resulting in increase of hemoglobin and erythrocytes. In some cases, there were increase of leucocytes and platelets.
