1) The take of mouse Sarcoma 37 cells was completely inhibited by incubating the tumor cells with aristolochic acid at the concentrations of 100-200 mcg/ml for 3 hours.
2) The inhibition ratio of 40-50% was obtained with 2.5-5 mg/kg doses of aristolochic acid on the subcutaneously implanted Sarcoma 37 tumor.
3) The treatment of ascitic Sarcoma 37 tumor with 1.255 mg/kg doses of aristolochic acid proved to show a remarkable prolongation of life-span of mice.
4) The cytopathic effect on HeLa cells in tissue culture was observed in concentrations of higher than 25 mcg/ml of aristolochic acid.
5) The treatment of mice with 5-25 mcg/kg of aristolochic acid proved to increase their carbon clearance activity.
6) Some protective effects of mice against bacterial infections includingStaphylococcus aureus, Diplococcus pneumoniaeandStreptococcus pyogenescould be obtained by the pretreatment with about 50 mcg/kg of aristolochic acid.
7) The phagocytic activity of peritoneal macrophages of mice could markedly be stimulated by the administration of 10-100 mcg/kg of aristolochic acid.
