腎臓半月体形成に関する実験的研究

抄録

As is well known, crescent formation is seen in the glomerulus in cases of chronic and subacute nephritis among various diseases of the kidney and this represents an important basis for the differentiation of renal diseases.
In the present experiment, crescnt formation was histologically studied among the changes in the renal glomerulus of rabbits given phenylhydrazine and naphthalin.
Crescent formation was found in 4 cases given a low dose and 2 cases given a medium dose of phenylhydrazine, totaling 6 cases and those with long survival. However, no crescent formation was seen in those given naphthalin.
Histologically, fibrous crescent was encountered in most cases, while epithelial crescent formation cannot be entirely ruled out.
Based on the present experiment, long survival and relatively slow and persistent tissure injury especially intercapillary hydrops appear to be the prerequisite for crescent formation.