1977 年 37 巻 3 号 p. 253-262
The reagin type of allergy and the hyperreactivity of air way play the important role in the etiology of bronchial asthma and it seems that the function of β-receptor is closely related to the both. Asthmatics and normal individuals were given Salbutamol as selective β2-stimulant and the changes of plasma cyclic AMP, lymphocyte cyclic AMP, blood sugar, blood pressure and blood eosinophils before and after administration of Salbutamol were evaluated. Cyclic AMP was measured by the method of protein binding assay.
The following results were obtained.
1) There were no significant differences in the plasma and lymphocyte cyclic AMP levels before administration of Salbutamol between asthmatics and normal individuals.
2) The cyclic AMP levels and the blood sugar levels were increased and the minimum blood pressure and the number of blood eosinophils were decreased after administration of Salbutamol in asthmatics and normal individuals.
3) Except the number of blood eosinophils and the blood sugar level, there were no significant differences at the rate of change in parameters of β-effect between asthmatics and normal individuals, but it seemed that asthmatics had a tendency of low rate of change as compared with normal individuals, so it was thought that there was the functional defect of 13-receptor in asthmatics.
4) There were significant correlations between the changes of cyclic AMP level and the change of some other parameters of β-effect, but there was not the same tendency bet-ween asthmatics and normal individuals.