生体医工学
Online ISSN : 1881-4379
Print ISSN : 1347-443X
ISSN-L : 1347-443X
研究
貫壁性不均一性が心エネルギー効率に与える影響に関する理論的解析
長谷川 雄基三島 充晴嶋吉 隆夫天野 晃松田 哲也
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2014 年 52 巻 3 号 p. 129-135

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Although there are numerous reports on the electrical heterogeneity of the myocardium, little has been given attention to its relation to cardiovascular mechanics, because of difficulties of simultaneously observing multiple effects in vivo. In this research, a multi-scale cardiovascular simulation model, which describes the myocyte physiology, left ventricular structural dynamics, and hemodynamics, was used to theoretically investigate the relationship between the electrical transmural heterogeneity of myocytes and ventricular energetics. The parameters which describe the characteristics of ion channels of an existing myocyte model were changed to create endo-, mid-, and epi-cardium myocyte models. Simulations were performed with electrically heterogeneous and homogeneous models. As a result, the heterogeneous model had lower contractility and higher total mechanical energy generation per ATP consumption. These findings indicate that electrical heterogeneity contribute to cardiac efficiency.

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© 2014 社団法人日本生体医工学会
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