シンポジウム
Imaging of deeply-placed cancerous lesions using 5-aminolevulinic acid with lanthanide nanoparticles
2014 年 52 巻 Supplement 号 p. SY-64-SY-66
詳細
2014 年 52 巻 Supplement 号 p. SY-64-SY-66
Introduction
A precise preoperative staging is necessary to determine the appropriate treatment strategy for digestive organ cancer. However, the accurate diagnosis is difficult. 5-Aminolevulinic acid (5-ALA) has metabolized protoporphyrinIX (PpIX) in a cancer cell. Lanthanide nanoparticles (LNPs) by the near-infrared (NIR) irradiation emits the light can excite PpIX. We investigated whether can be observed in the deeply-placed cancer be used in 5-ALA and LNPs combination.
Methods
We administered LNPs to tumor-bearing mouse model, and examine its pharmacokinetics. Mouse model incorporating gastric cancer cells were studied after administration only LNPs and administration of mixture of 5-ALA and LNPs by NIR irradiation.
Results
LNPs were accumulated in the cancer lesion. LNPs emission was observed in the tumor lesion. The cancer lesions were detectable on PpIX fluorescence imaging was by near NIR excitation.
Conclusions
These results suggested that fluorescence diagnosis of deeply-placed cancer may be possible by using the mixture 5-ALA and LNPs.
