Atmospheric-pressure plasmas can sterilizing, disinfecting, and disintegrating hazardous materials and modifying material surfaces. Plasma and pulsed electric field technologies have diverse applications, such as skin regeneration by multiple low-energy plasma therapy. Cord blood has hematopoietic stem cells, it has been put to practical use in hematopoietic stem cell transplantation. In addition, the presence of mesenchymal stem cells found in the umbilical cord blood, application to regenerative medicine has been expected. On the other hand, HIE is a condition in which the brain does not receive enough oxygen. Atmospheric-pressure plasmas acts to HIE, angiogenesis is promoted. We expected angiogenesis improving the ischemic condition can be recovery of brain function. And, umbilical cord blood can be expected to play the effect of precursor cells to the HIE. We investigate the method of plasma and cord blood administration and the effect of each method to the HIE model rats.
