In vivo イメージングを目指した小分子可視化プローブの開発と応用：近赤外蛍光プローブ及びMRIプローブ

抄録

Fluorescence imaging is one of the most powerful techniques for visualization of the temporal and spatial biological events in living cells, and fluorescent probes are also highly useful for fluorescence imaging. The light in near-infrared (NIR) region is recently paid much attention because of its high tissue penetration and low autofluorescence. In this presentation, we will report the development of small-molecule NIR fluorescent probes for hypoxia (Angew. Chem. Int. Ed., 52, 13028-13032 (2013)) and a small-molecule MRI-fluorescence dual imaging probe for atherosclerosis that specifically targets the atherosclerotic environment (Org. Biomol. Chem., 12, 8611-8618 (2014)).