自発的身体活動の強縦断データによる双極性障害の連続病態把握と病相遷移予測

抄録

We found the robust statistical laws of behavioral organization, specifically the laws of durations of resting and active periods in spontaneous physical activity (SPA), as well as their alterations in psychiatric disorders, including major depressive disorder. These strongly suggest the existence of the dynamical system organizing SPA and its dysfunctions in the disorders. In this talk, we introduce our recent studies on the reconstruction of the dynamical systems based on SPA in patients with psychiatric disorders, showing the alterations of their dynamical properties in the disorders. Further, using the intensive longitudinal data of SPA in patients with bipolar disorder, we demonstrate the concurrent changes of the reconstructed systems, associated with pathological states or clinical phases, along with the nontrivial changes around the vicinity of clinical phase transitions. These could lead to the objective monitoring of pathological states of psychiatric disorders and an early warning detection of pathological changes.