Plasma is called the 4th state of matter, it has been widely used in industrial field.However, in recent years, various applications have been reported in medical field.Especially, atmospheric-pressure plasma effects such as cell proliferation, angiogenesis and vasodilation have been reported, and expectations are growing that it will lead to new disease treatment.In this study, we observed the action of atmospheric-pressure plasma exposure/inhalation on blood vessels, and considered applications for treatment of hypoxic ischemic encephalopathy (HIE) there is no effective treatment method presently.Accordingly first in this study, in order to create a stable HIE model, we performed ligature of the common carotid artery on one side, and then exposure to 8% oxygen to reduce the volume of blood flow to the brain.As a result, we were able to identify the cerebral edema responsible for the ischemia within the specimen.
