2018 Volume Annual56 Issue Abstract Pages S152
ECMO system has been used for over days to weeks. However, its performance deterioration, poor antithrombogenicity and large apparatus are still problematic issue. In this study, we developed a compact ECMO system with built-in monitors and evaluated its prototype in chronic animal experiments. This system is consisted of a pre-connected blood circuit unit, a pump driver unit integrating with measurement instruments and a gas bomb unit. The circuit was consisted of a centrifugal pump (BIOFLOAT NCVC), an oxygenator (BIOCUBE) and built-in sensors. A driver was made as extremely compact (W290 x D205 x H260 mm, 6.6 kg). ECMO with the prototype was conducted for 4 weeks using 3 adult goats. In all cases, the ECMO could run for 28 days without device exchange and monitored stably. Thrombus formation was hardly observed in the each circuits. The prototype demonstrated durability, stability of monitors and thrombo-resistant property for mid-long term.
