Abstract
In order to prevent the brain blood vessel system disease, recently, arteriosclerosis index of the pulse wave capable of examining the degree of the arteriosclerosis invasively and safely is noticed. This index second derivative of pulse wave with time is called the acceleration pulse wave and is started to use in the clinical feild, however, scientific verification is not yet made. In this study, the usefulness of the acceleration pulse wave is clarified by experiment and numerical simulations based on mathematical modeling.