DNAアプタマー架橋構造色ゲルセンサを用いた生化学物質のモニタリング

抄録

This paper describes a DNA aptamer linked structural color hydrogel sensor that can optically detect silver ions by naked eyes and camera-based smart devices. Structural color is expressed by Bragg's diffraction of colloid crystal. DNA aptamer is single-stranded DNA that binds to a specific target molecule and changes its secondary structure. The hydrogel integrating colloid crystal and DNA aptamer can convert the target concentration to visible color change, which can be detected by human naked eyes. As a preparation for fabricating the gel sensor, we fabricated a silica colloid crystal solution and controlled the color by arranging its particle concentration. In addition, we confirmed the response of DNA aptamer linked gel to silver acetate solution. This sensor could be applied to various areas such as point of care testing, food and water safety, and so on. We believe that our approach could be effective to construct aptamer-based optical biosensors.