マイクロ流体中における細胞の変形と応力の関係

抄録

A microfluidic channel is one of the best tools for the evaluation of red blood cell (RBC) deformability in a short time with just a tiny amount of sample blood. We have proposed a novel method to evaluate both viscosity and elasticity of a RBC in a microfluidic channel. For more precise evaluation of stress exerted on a RBC in a realistic situation, here we performed fluid simulation by finite element method. Calculating the flow profile and corresponding stress applied on the surface of a RBC, we obtained Young’s modulus and viscoelastic parameters through the image analysis of the cell flowing in the microchannel.