Development of Cartridge-type Measurement System for Cerebral Organoid

Abstract

Cerebral organoids, that is cultured from iPS cells, are known as a counterpart of the human brain. Interestingly, some researchers reported cerebral organoids exhibit adaptive reservoir computation ability with biological neural networks. Therefore, we expect that the cerebral organoids can be used as a processing unit for robots, and we can develop novel intelligent systems using cerebral organoids. In this study, we aim to develop a cartridge-type measurement system so that we can measure the neural activity of a cerebral organoid and observe with a microscope simultaneously. As a result, we confirmed that we got time developments of neuronal firing and computation results of spike sorting. We observed a cerebral organoid inside the chamber with a microscope at the same time of activity measurement. In future work, we expect we can implement cerebral organoids into the robotic systems via the proposed cartridge-type measurement system.