高脂肪食および高炭水化物食投与時の脂質代謝にかんする生化学的および電顕的研究

抄録

The feeding of high fat diet induced fatty liver, while the feeding of high carbohydrate diet caused hyperlipemia. In the case of the high fat diet, triglyceride was deposited markedly in the liver (namely, deposited type). Elevated levels of serum triglyceride might result from increased secretion of triglyceride from the liver (namely, secreted type).
No difference in cholinephosphotransferase activity was observed between the two groups. In contrast, diacylglycerol acyltransferase activity was higher in rats fed the high fat diet than in those fed the high carbohydrate diet.
The lipoprotein lipase activities in both the plasma after heparin injection and the adipose tissues were similar in the two groups, suggesting that the delivery of triglyceride from the plasma to the adipose tissue proceeds at a similar rate between the two groups.
Morphological examination revealed an increased number or size of lipid droplets in the liver cell cytoplasm of rats fed the high fat diet.