Lipid Metabolism of the Liver and Epididymal Adipose Tissue in Rats Fed Choline-Deficient or Choline-Supplement Diet

Abstract

Choline-deficient diet induced fatty liver in rats derived from the accumulation of triglyceride. No reduction was observed in the level of liver phospholipid and the activity of cholinephosphotransferase in choline-deficient rats when compared with those receiving a choline-supplement. These results indicated that the accumulation of liver triglyceride during choline deficiency was not accompanied by the changes in liver phospholipid.
Decrease of triglyceride in the liver was observed in the choline-deficient rats after administering lecithin through a stomach tube. Decrease was also found in the level of serum triglyceride and cholesterol in this group. Mechanism of choline-deficient diet induced fatty liver was discussed on the basis of these results.