日本口腔インプラント学会誌
Online ISSN : 2187-9117
Print ISSN : 0914-6695
ISSN-L : 0914-6695
原著
キチン・キトサンに関する研究
―その9.キチン・キトサンを結合材とする骨補塡材のCaSiO₃添加に関する実験的研究:実験動物および培養細胞における評価―
森 厚二日高 勇一中島 三晴鬼澤 徹矢ヶ﨑 裕鈴木 和夫五十嵐 俊男伊藤 充雄
著者情報
ジャーナル フリー

1999 年 12 巻 2 号 p. 185-192

詳細
抄録

Three kinds of bone filling materials were prepared by combining powder, including CaO, CaSiO3 and hydroxyapatite (HAP), and chitin and chitosan. The proportion of CaO, CaSiO3 and HAP was 4.5%, 6.0% and 89.5%. This powder 0.54 g (A), 0.67 g (B) and 0.80 g (C) were kneaded with chitin and chitosan sol 2.2 g and hardened, respectively. These materials were evaluated in the experiment animal and osteoblastic cells. The purpose of this study was to discuss which materials were most desirable for the bone filling materials. In an animal experiment, tissue reactions were similar in each material and were characterized by granulation tissue formation with inflammation. In the osseous tissue, repairs at defected sites(B and C) and direct relationship between material A and bone were seen. Cultured cell examination revealed that DNA contents and alkaline phosphatase activity in material A were significantly higher than those in control. Results of this study indicated that material A, 0.54 g mixed in chitin and chitosan sol 2.2 g, was most effective for the bone formation.

著者関連情報
© 1999 公益社団法人日本口腔インプラント学会
次の記事
feedback
Top