チタン上の溝がラット頭頂骨の骨形成に及ぼす影響

抄録

To investigate the effects on bone formation of differences in surface topography of titanium plates, circular titanium plates (diameter of 6.0 mm) were manufactured with a groove of 30 μm or 120 μm depth semilaterally on the machined surface, or with no groove as the control machined surface. We then embedded the plates in parietal bone defects of rats, and compared the histology of the central and peripheral areas of neonatal bone growth formed on the plate surfaces. Quantitative analysis was performed using a stereoscopic microscope, using Alizarin Red S to digitize the concentrations of unstained and stained portions. The comparative results of the surface area of neonatal bone per unit area of each measurement region led to the following conclusions.
1. The grooved surfaces showed a significantly higher amount of neonatal bone formation than the control surface.
2. There was no significant difference in neonatal bone formation between the 30 μm and 120 μm grooved surfaces.
3. There was no significant difference in neonatal bone formation between the peripheral areas of the grooved surface and control surface.
4. There was a highly significant difference in neonatal bone formation between the central areas of the grooved surface and control surface.
5. In the peripheral and central areas of the grooved surface, neonatal bone formation showed a high, positive correlation of R²=0.62
These conclusions indicate that a titanium plate with a groove on one side can act as a beneficial scaffold for neonatal bone formation.